The Alliance for Maternal and Newborn Health Improvement (AMANHI) study in Pemba has been established to best characterize population based longitudinal cohort of pregnant women and their babies in sub–Saharan Africa. Our goal is to establish and maintain a bio-bank in resource limited setting in East Africa; develop local capacity around bio-banking and the use of biological samples to explore future hypotheses as new methods and technologies become available to advance knowledge on key adverse pregnancy outcomes including preterm births, miscarriages, still births, IUGR and SGA. Population-based bio-banks will help translate -omics discoveries into promising diagnostic, treatment and prevention strategies that can be further tested in intervention trials. The integration of genome-based knowledge into epidemiological and public health research, policies and health services seems to be the most important public health challenge. Having a characterized cohort of pregnancy with all the metadata presents a unique opportunity to investigate clinical, biochemical markers and add these data to the database having metadata, omics data and outcomes of pregnancy both as associations and etiological path analysis.
- Perform comprehensive ‘omics’ analysis to identify new biology that informs novel preventative, diagnostic, and therapeutic approaches for priority conditions: preeclampsia (PE), preterm birth (PTB), stillbirth (SB), intrauterine growth restriction (IUGR) and sepsis.
- Create a developmental clock that will provide more precise information on the status of a fetus during pregnancy than is currently determined using current methods of gestational age assessment
- Advance the MOMI Consortium’s capacity to risk stratify pregnancies and at-risk newborn into optimal prevention/treatment protocols.
Ki GC Africa (Knowledge Integration Grand Challenges):
- Better care during pregnancy.
- Better care at birth.
- Better postnatal care for women and their newborns, and
- Better hospital care of sick newborns (see report from the September 2018 policy workshop organized by the African Academy of Sciences (AAS) and the UK Academy of Medical Sciences).