Breakthrough infections with SARS-CoV-2 omicron despite mRNA vaccine booster dose

The most recent SARS-CoV-2 variant of concern to emerge has been named omicron.1 Its
immune evasion potential was predicted by genomic data and has been preliminarily
confirmed by observations of an increased incidence of reinfections and breakthrough
infections.2 This has triggered calls to intensify vaccination programmes including
provision of vaccine booster doses.3

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